![]() BARNARDS data are owned by the Ineos Oxford Institute for Antimicrobial Resistance. ![]() In this analysis, we used CHAMPS Level 2: De-Identified Data, which are all available at the following link after signing a data transfer agreement. The CHAMPS data are freely available online upon request. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All underlying model code and freely and publicly available data (i.e., CHERG and GBD data, maternal tetanus vaccination rates) that were used in this analysis are available from. Received: OctoAccepted: ApPublished: May 22, 2023Ĭopyright: © 2023 Kumar et al. (2023) Global, regional, and national estimates of the impact of a maternal Klebsiella pneumoniae vaccine: A Bayesian modeling analysis. pneumoniae neonatal sepsis deaths and is unable to consider within-country variability in bacterial prevalence that may impact the projected burden of sepsis.Ĭitation: Kumar CK, Sands K, Walsh TR, O’Brien S, Sharland M, Lewnard JA, et al. Nevertheless, our modeling only considers country-level trends in K. The largest relative benefits are in Africa (Sierra Leone, Mali, Niger) and South-East Asia (Bangladesh) where vaccination could avert over 5% of all neonatal deaths. Globally, we estimate that maternal vaccination could avert 80,258 neonatal deaths and 399,015 neonatal sepsis cases yearly worldwide, accounting for more than 1.49% of all neonatal deaths. Resistance rates to carbapenems are increasing most rapidly and 22.43% of neonatal sepsis deaths are caused by meropenem-resistant K. pneumoniae isolates to predict the future number of drug-resistant cases and deaths that could be averted by vaccination. ![]() pneumoniae genomes from human isolates gathered globally from 2001 to 2020 to quantify the temporal rate of acquisition of AMR genes in K. Within these studies, 26.95% of fatal neonatal sepsis cases were culture-positive for K. To parameterize our model, we used data from 3 global studies of neonatal sepsis and/or mortality-with 2,330 neonates who died with sepsis surveilled from 2016 to 2020 undertaken in 18 mainly LMICs across all WHO regions (Ethiopia, Kenya, Mali, Mozambique, Nigeria, Rwanda, Sierra Leone, South Africa, Uganda, Brazil, Italy, Greece, Pakistan, Bangladesh, India, Thailand, China, and Vietnam). pneumoniae maternal vaccine with 70% efficacy administered with coverage equivalent to that of the maternal tetanus vaccine on neonatal sepsis infections and mortality. We developed a Bayesian mixture-modeling framework to estimate the effects of a hypothetical K.
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